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PDCD1/CD279靶点

CD279(Gene ID:5133)在20世纪90年代末被发现,是免疫检查点受体CD28/CTLA-4家族的一员。与为T细胞活化提供共刺激信号的CD28不同,CD279在与其配体PD-L1 (B7-H1)和PD-L2 (B7-DC)结合时传递抑制信号,表达于各种细胞,包括癌细胞和抗原呈递细胞(APCs)。这种相互作用对于维持免疫稳态和防止过度免疫反应至关重要。CD279的主要功能如下:

1. 免疫检查点调节:CD279是免疫反应的重要调节因子。当与其配体结合时,CD279传递抑制信号,抑制T细胞活化和增殖,防止过度的免疫反应。这种机制对于避免自身免疫和免疫介导的组织损伤至关重要。

2. T细胞衰竭:CD279与T细胞衰竭密切相关,T细胞衰竭是一种在慢性感染和癌症中常见的功能障碍状态。持续的CD279信号传导可损害T细胞效应子功能,导致针对持续病原体或肿瘤的无效免疫反应。

3. 癌症中的免疫逃避:许多癌细胞利用PD-1途径来逃避免疫监视。通过上调PD-L1表达,癌细胞可以抑制肿瘤特异性T细胞的细胞毒性,从而允许肿瘤生长和免疫逃逸。

4. 治疗靶点:CD279已经成为癌症免疫治疗的重要靶点。已经开发了靶向CD279或其配体的单克隆抗体来阻断抑制性信号传导并增强抗肿瘤免疫反应。像pembrolizumab和nivolumab这样的药物在治疗各种癌症方面取得了显著的成功。

5. 自身免疫性疾病:CD279信号传导失调可导致自身免疫性疾病,因为过度抑制T细胞反应可能导致免疫耐受崩溃。理解和调节CD279信号在自身免疫性疾病治疗的发展中至关重要。

卡梅德生物是一家专注于生物技术领域的创新公司,致力于为科研机构、高校和公司提供高质量的PDCD1/CD279蛋白、PDCD1/CD279抗体等高质量的靶点产品。卡梅德生物始终秉承着客户至上的原则,致力于为科研机构、高校和公司提供最优质的PDCD1/CD279相关产品,推动生物技术领域的不断创新和发展。

 

卡梅德推出的特色靶点PDCD1/CD279蛋白产品:

 

编号

产品名称

物种

宿主

规格

询价

KMPH1429

Human PDCD1LG2 Protein, His & Fc Tag

Human

HEK293 Cells

100ug, 200ug

询价

KMPH1430

Human PDCD1LG2 Protein, His Tag

Human

HEK293 Cells

100ug, 200ug

询价

KMPH1533

Human PDCD1 Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH1534

Human PDCD1 Protein, His Tag

Human

HEK293 Cells

50ug, 100ug

询价

MOP1135

Mouse PDCD1 Protein, Fc & His Tag

Mouse

HEK293 Cells

100ug, 200ug

询价

MOP1136

Mouse PDCD1 Protein, His Tag

Mouse

HEK293 Cells

100ug, 200ug

询价

MOP1691

Mouse PDCD1LG2 Protein, Fc Tag

Mouse

HEK293 Cells

100ug, 200ug

询价

MOP1692

Mouse PDCD1LG2 Protein, His Tag

Mouse

HEK293 Cells

100ug, 200ug

询价

PM296

Cynomolgus PDCD1LG2 Protein, Fc Tag

Cynomolgus

HEK293 Cells

100ug, 200ug

询价

PM297

Cynomolgus PDCD1LG2 Protein, His Tag

Cynomolgus

HEK293 Cells

100ug, 200ug

询价

KMPH5864

Human PDCD1 Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5865

Human PDCD1 Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5866

Human PDCD1 Protein, Fc Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5867

Human PDCD1 Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5868

Human PDCD1 Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5869

Human PDCD1 Protein, Fc Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5870

Human PDCD1 Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5871

Human PDCD1 Protein

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5872

Human PDCD1 Protein, Fc Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5873

Human PDCD1 Protein, Fc & Avi Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5874

Human PDCD1 Protein, Fc & Avi Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5875

Human PDCD1 Protein, Strep Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5876

Human PDCD1 Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5877

Human PDCD1 Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5878

Human PDCD1 Protein, Fc Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5879

Human PDCD1 Protein, Fc Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5880

Human PDCD1 Protein, Fc & Avi Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5893

Human PDCD1LG2 Protein, His & Fc Tag

Human

HEK293 Cells

100ug, 200ug

询价

 

卡梅德推出的特色靶点PDCD1/CD279抗体产品:

 

编号

产品名称

物种

宿主

应用

规格

询价

PA5704

Rabbit Anti-Human PDCD1 pAb

Human

Rabbit

WB, IHC, IF

50ul, 100ul

询价

PA9042

Rabbit Anti-Human PDCD10 pAb

Human

Rabbit

WB, IF

50ul, 100ul

询价

PA10709

Rabbit Anti-Human PDCD10 pAb

Human

Rabbit

WB, IHC

50ul, 100ul

询价

PA11371

Rabbit Anti-Human PDCD1LG2 Polyclonal Antibody

Human

Rabbit

WB

50ul, 100ul

询价

PA13127

Rabbit Anti-Human PDCD10 pAb

Human

Rabbit

IHC

50ul, 100ul

询价

 

卡梅德其他优势产品:

 

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病毒蛋白

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