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ICOS/CD278靶点

CD278(Gene ID:29851)在21世纪初被鉴定为CD28/CTLA-4共刺激分子家族的成员。它的表达在T细胞激活时是可诱导的,因此被命名为“可诱导的T细胞共刺激因子”。CD278与其配体ICOS配体(ICOS 1或B7h)相互作用,主要在抗原呈递细胞(APCs)如树突细胞和B细胞上表达。这种相互作用提供了增强T细胞活化和功能的共刺激信号。CD278的主要功能如下:

1. T细胞活化:CD278通过参与增强T细胞受体(TCR)信号传导来促进T细胞的活化。它导致细胞因子产生增加,包括对各种免疫反应至关重要的IL-4、IL-10和IL-21。

2. T滤泡辅助(Tfh)细胞分化:CD278对Tfh细胞的分化和功能至关重要,Tfh细胞在生发中心反应期间对B细胞的帮助至关重要。Tfh细胞大量表达CD278,对高亲和力抗体的产生至关重要。

3. 抗体反应:CD278介导的Tfh细胞对于B细胞中抗体类别转换和亲和力成熟至关重要。CD278或ICOSL缺陷导致抗体反应受损,从而增加感染的易感性。

4. 调节性T细胞(Treg)稳定性:CD278在Treg上表达,并在维持其稳定性和抑制功能中发挥作用。CD278信号传导的中断可导致免疫反应失调和自身免疫性疾病。

5. 免疫耐受:CD278与免疫耐受和自身免疫预防有关。CD278信号的失调可能导致免疫耐受机制的崩溃。

6.免疫相关疾病:异常CD278信号与自身免疫性疾病相关,如系统性红斑狼疮(SLE)和类风湿性关节炎,突出了其在维持免疫稳态中的重要性。

卡梅德生物是一家专注于生物技术领域的创新公司,致力于为科研机构、高校和公司提供高质量的ICOS/CD278蛋白、ICOS/CD278抗体等高质量的靶点产品。卡梅德生物始终秉承着客户至上的原则,致力于为科研机构、高校和公司提供最优质的ICOS/CD278相关产品,推动生物技术领域的不断创新和发展。

 

卡梅德推出的特色靶点ICOS/CD278蛋白产品:

 

编号

产品名称

物种

宿主

规格

询价

KMPH1487

Human ICOS Protein, Fc & His Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH3259

Human ICOSLG Protein, Fc Tag

Human

HEK293 Cells

100ug, 200ug

询价

KMPH3260

Human ICOSLG Protein, His Tag

Human

HEK293 Cells

100ug, 200ug

询价

MOP1185

Mouse ICOSLG Protein, Fc & His Tag

Mouse

HEK293 Cells

100ug, 200ug

询价

MOP1186

Mouse ICOSLG Protein, His Tag

Mouse

HEK293 Cells

100ug, 200ug

询价

MOP1356

Mouse ICOS Protein, Fc Tag

Mouse

HEK293 Cells

100ug, 200ug

询价

PR368

Rat ICOS Protein, Fc Tag

Rat

HEK293 Cells

50ug, 100ug

询价

KMPH5853

Human ICOS Protein, Fc Tag

Human

HEK293 Cells

50ug, 100ug

询价

KMPH5915

Human ICOSLG Protein, Fc Tag

Human

HEK293 Cells

100ug, 200ug

询价

KMH424

Recombinant Human CD275/ICOSLG Protein, His Tag

Human

Mammalian cells

50ug, 100ug

询价

KMH427

Recombinant Human CD278/ICOS Protein, Fc Tag

Human

Mammalian cells

50ug, 100ug

询价

KMH512

Recombinant Human ICOSLG Protein, His Tag

Human

Mammalian cells

50ug, 100ug

询价

MOP2075

Recombinant Mouse B7-h2/Icoslg/CD275/Icosl Protein, His Tag

Mouse

Mammalian cells

50ug, 100ug

询价

KMH1238

Recombinant Human ICOS Protein, Fc Tag

Human

Mammalian cells

50ug, 100ug

询价

MOP2177

Recombinant Mouse Icos/AILIM/CD278 Protein, His Tag

Mouse

Mammalian cells

50ug, 100ug

询价

KMH1239

Recombinant Human ICOSLG Protein, His Tag

Human

Mammalian cells

50ug, 100ug

询价

KMP2561

Human ICOS Protein, hFc Tag

Human

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP2562

Human ICOS Protein, rFc Tag

Human

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP2898

Human ICOS ligand Protein, His Tag

Human

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP2899

Human ICOS ligand Protein

Human

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP3689

Cynomolgus ICOS ligand Protein, hFc Tag

Cynomolgus

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP3915

Mouse ICOS Protein, His Tag

Mouse

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP3916

Mouse ICOS Protein, rFc Tag

Mouse

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP3917

Mouse ICOS Protein, hFc Tag, Avi Tag

Mouse

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP4265

Rat ICOS ligand Protein, hFc Tag

Rat

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP4266

Rat ICOS ligand Protein, His Tag

Rat

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP4333

Rhesus ICOS Protein, hFc Tag

Rhesus

HEK293 Cells

50ug, 100ug, 200ug

询价

KMP4334

Rhesus ICOS Protein, hFc Tag, Avi Tag

Rhesus

HEK293 Cells

50ug, 100ug, 200ug

询价

 

卡梅德推出的特色靶点ICOS/CD278抗体产品:

 

编号

产品名称

物种

宿主

应用

规格

询价

PA11541

Rabbit Anti-Human ICOS Polyclonal Antibody

Human

Rabbit

WB, IF

50ul, 100ul

询价

PA15392

Rabbit Anti-Human ICOSLG pAb

Human

Rabbit

WB, IHC

50ul, 100ul

询价

MA1216

Rabbit Anti-Human ICOS mAb

Human

Rabbit

WB

50ul, 100ul

询价

 

卡梅德其他优势产品:

 

重组蛋白

病毒蛋白

细菌蛋白