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Recombinant Human anti-COVID-19/SARS-CoV-2 S1 Monoclonal Antibody产品信息
产品编号 MAV115
产品名称 Recombinant Human anti-COVID-19/SARS-CoV-2 S1 Monoclonal Antibody
抗体亚型 IgM
克隆号 3D6
产品别名 SARS-CoV-2 S1 protein antibody, 2019-nCoV, Coronavirus
规格 100ul, 500ul
规格与价格 100ul/¥2,300; 500ul/¥6,500
物种 COVID-19
宿主 Human
免疫原 Native virus
产品应用 ELISA, Colloidal Gold, POCT, Neutralizaiton , Standard Positive Control
生物活性 IC50 = 34 ng/mL using using ELISA method
缓冲体系 0.01M PBS, pH 7.4
产品背景 A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor.
保存条件 This product can be stored at 2℃-8℃ for one month. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
备注 This product is used for research use only. Not for human or diagnostic use.